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I doubt there would be any appreciable reduction in flow due to barbed fittings vs. any other type of fitting because they are pretty smooth on the inside. Hose/pipe diameter and the number of bends does have a greater effect on flow.
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my build:
http://www.reefcentral.com/forums/showthread.php?t=2512689
my fuge thread:
http://reefcentral.com/forums/showthread.php?t=2523500
Current Tank Info: DSA NEO 65G reef powered by Kessil
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