OT: WoooHooo my new phosphate binder moves into clinical trials!

Randy Holmes-Farley · 01/13/2009, 03:58 PM

I know its off topic, and for those who do not follow my real world activities, just ignore this thread, but for those who do, this is what I've been spending a lot of my time on for the past few years...

My previously approved compounds for phosphate binding in people are Renagel and Renvela, but we just filed for a new phosphate binding therapy:

http://www.businesswire.com/portal/s...00618&vnsId=33

from it:

Genzymeâ€™s Cardiometabolic and Renal segment generated revenue of $956 million in 2008, a 15 percent increase over $833 million in 2007, and is on track to generate approximately $1.4 billion annually by 2011. Key drivers will include the sustained growth of the companyâ€™s sevelamer therapies RenagelÂ® (sevelamer hydrochloride) and Renvela. The increasing use of these products globally and the anticipated expansion of Renvelaâ€™s U.S. indication to include the treatment of patients with chronic kidney disease who are not on dialysis are expected to act as principal catalysts for this growth.

Fourth-quarter sales of sevelamer were $169 million, compared with $166 million in the previous fourth quarter. For the year, sales increased 13 percent to $678 million, compared with $603 million the year before.

Genzyme has filed an IND for an advanced phosphate binder (APB) and expects to begin a phase 2/3 trial this year. The APB is designed to more effectively bind phosphate for a substantial improvement in potency over existing therapies while maintaining all of the benefits of sevelamer.

Sk8r · 01/13/2009, 03:59 PM

Congrats! This is big!

HighlandReefer · 01/13/2009, 04:09 PM

Congrats Randy. Sounds like we should buy stock in Genzyme.

mkbtank · 01/13/2009, 04:13 PM

WOW! Talk about making a difference.....

Amazing, Randy!

Randy Holmes-Farley · 01/13/2009, 06:59 PM

Thanks, folks.

redfishsc · 01/13/2009, 07:45 PM

Do you make a reactor I can plumb into my sump

Billybeau1 · 01/13/2009, 10:07 PM

Attaboy RHF.

CIGDAZE · 01/14/2009, 07:50 AM

Congrats! That's awesome. Good luck.

Boomer · 01/14/2009, 02:25 PM

Now that is cool. You did it again

cs12109 · 01/14/2009, 02:30 PM

Randy, I see a really large, new, shiny tank in your future! Congratulations!

redfishsc · 01/14/2009, 05:19 PM

On second thought, Randy, ever considered using the IV drips to drip kalkwasser into the patients.... maybe the kalk will precipitate the phosphate out of solution... and perhaps even reverse osteoporosis...

kgross · 01/14/2009, 05:51 PM

Congratulations sir.

Kim

rhoptowit · 01/14/2009, 11:25 PM

congrats randy!

bertoni · 01/15/2009, 01:08 AM

Congratulations! Very, very cool!

Randy Holmes-Farley · 01/15/2009, 05:54 AM

Thanks very much everyone.

tmz · 01/15/2009, 11:22 AM

Nice work: important work. Congratulations, Randy.

01/13/2009, 03:58 PM	#1
Randy Holmes-Farley Reef Chemist Join Date: Apr 2001 Location: Arlington, Massachusetts Posts: 86,233	OT: WoooHooo my new phosphate binder moves into clinical trials! I know its off topic, and for those who do not follow my real world activities, just ignore this thread, but for those who do, this is what I've been spending a lot of my time on for the past few years... My previously approved compounds for phosphate binding in people are Renagel and Renvela, but we just filed for a new phosphate binding therapy: http://www.businesswire.com/portal/s...00618&vnsId=33 from it: Genzymeâ€™s Cardiometabolic and Renal segment generated revenue of $956 million in 2008, a 15 percent increase over $833 million in 2007, and is on track to generate approximately $1.4 billion annually by 2011. Key drivers will include the sustained growth of the companyâ€™s sevelamer therapies RenagelÂ® (sevelamer hydrochloride) and Renvela. The increasing use of these products globally and the anticipated expansion of Renvelaâ€™s U.S. indication to include the treatment of patients with chronic kidney disease who are not on dialysis are expected to act as principal catalysts for this growth. Fourth-quarter sales of sevelamer were $169 million, compared with $166 million in the previous fourth quarter. For the year, sales increased 13 percent to $678 million, compared with $603 million the year before. Genzyme has filed an IND for an advanced phosphate binder (APB) and expects to begin a phase 2/3 trial this year. The APB is designed to more effectively bind phosphate for a substantial improvement in potency over existing therapies while maintaining all of the benefits of sevelamer. __________________ Randy Holmes-Farley Current Tank Info: 120 mixed reef

01/13/2009, 03:59 PM	#2
Sk8r RC Mod Join Date: Feb 2006 Location: Spokane WA Posts: 34,628 Blog Entries: 55	Congrats! This is big! __________________ Sk8r Salinity 1.024-6; alkalinity 8.3-9.3 on KH scale; calcium 420; magnesium 1300, temp 78-80, nitrate .2. Ammonia 0. No filters: lps tank. Alk and cal won't rise if mg is low. Current Tank Info: 105g AquaVim wedge, yellow tang, sailfin blenny,royal gramma, ocellaris clown pair, yellow watchman, 100 microceriths, 25 tiny hermits, a 4" conch, 1" nassarius, recovering from 2 year hiatus with daily water change of 10%.

01/13/2009, 04:09 PM	#3
HighlandReefer Team RC Member Join Date: Aug 2008 Location: Highland, Maryland Entomologist Posts: 14,591	Congrats Randy. Sounds like we should buy stock in Genzyme. __________________ Cliff Babcock Intestests: Digital Microscopy; Marine Pest Control; Marine Plants & Macroalgae Current Tank Info: 180 g. mixed reef system

01/13/2009, 06:59 PM	#5
Randy Holmes-Farley Reef Chemist Join Date: Apr 2001 Location: Arlington, Massachusetts Posts: 86,233	Thanks, folks. __________________ Randy Holmes-Farley Current Tank Info: 120 mixed reef

01/13/2009, 07:45 PM	#6
redfishsc Registered Member Join Date: Sep 2008 Location: Wake Forest, NC Posts: 3,696	Do you make a reactor I can plumb into my sump __________________ "The measure of a life is not its duration but its donation." Corrie Ten Boom “The tyrant dies and his rule is over, the martyr dies and his rule begins” -- Søren Kierkegaard Current Tank Info: ghetto grad school reef.....11g rimless tank, 36X9X9, lit by Cree and Rebels scobbled together. Stocked mostly with free stuff I got from panhandling my fellow reefers.

01/13/2009, 04:13 PM	#4
mkbtank Premium Member Join Date: Apr 2007 Location: NE Philadelphia Posts: 1,164	WOW! Talk about making a difference..... Amazing, Randy!

01/13/2009, 10:07 PM	#7
Billybeau1 Registered Member Join Date: Jul 2005 Location: Dyer, Indiana Posts: 12,010	Attaboy RHF.

01/14/2009, 07:50 AM	#8
CIGDAZE Registered Member Join Date: Sep 2008 Location: St. Petersburg, FL Posts: 136	Congrats! That's awesome. Good luck.

01/14/2009, 02:25 PM	#9
Boomer Bomb Technician (EOD) Join Date: Aug 2002 Location: Duluth, Minnesota Posts: 11,842	Now that is cool. You did it again __________________ If you See Me Running You Better Catch-Up Seawater Chemistry, Geology, ID Marine Life, Collecting Science Books, Explosives Technology, Audiophile An explosion can be defined as a loud noise, accompanied by the sudden going away of things, from a place where they use to be.

01/14/2009, 02:30 PM	#10
cs12109 Registered Member Join Date: Dec 2008 Posts: 74	Randy, I see a really large, new, shiny tank in your future! Congratulations!

01/14/2009, 05:19 PM	#11
redfishsc Registered Member Join Date: Sep 2008 Location: Wake Forest, NC Posts: 3,696	On second thought, Randy, ever considered using the IV drips to drip kalkwasser into the patients.... maybe the kalk will precipitate the phosphate out of solution... and perhaps even reverse osteoporosis... __________________ "The measure of a life is not its duration but its donation." Corrie Ten Boom “The tyrant dies and his rule is over, the martyr dies and his rule begins” -- Søren Kierkegaard Current Tank Info: ghetto grad school reef.....11g rimless tank, 36X9X9, lit by Cree and Rebels scobbled together. Stocked mostly with free stuff I got from panhandling my fellow reefers.

01/14/2009, 05:51 PM	#12
kgross Premium Member Join Date: Nov 1999 Location: Nampa, ID Posts: 5,870	Congratulations sir. Kim __________________ Proud Member of the Idaho Marine Aquarium Society America will only be the Land of the Free as long as it is the Home of the Brave. Current Tank Info: AGA 180gallon tank, VHO/MH lighting, DSB, calcium reactor, Also a 7 Gallon Nano softy tank, and a 32 gallon cube

01/14/2009, 11:25 PM	#13
rhoptowit Registered Member Join Date: Aug 2007 Posts: 415	congrats randy! __________________ the best democracy money can buy Current Tank Info: 65 gallon w/sump, ATB small, ATI PM, vortech, w/ DIY calcium rct

01/15/2009, 01:08 AM	#14
bertoni RC Mod Join Date: Mar 2002 Location: Mountain View, CA, USA Posts: 88,616	Congratulations! Very, very cool! __________________ Jonathan Bertoni

01/15/2009, 05:54 AM	#15
Randy Holmes-Farley Reef Chemist Join Date: Apr 2001 Location: Arlington, Massachusetts Posts: 86,233	Thanks very much everyone. __________________ Randy Holmes-Farley Current Tank Info: 120 mixed reef

01/15/2009, 11:22 AM	#16
tmz ReefKeeping Mag staff Join Date: Apr 2006 Location: West Seneca NY Posts: 27,691	Nice work: important work. Congratulations, Randy. __________________ Tom Current Tank Info: Tank of the Month , November 2011 : 600gal integrated system: 3 display tanks (120 g, 90g, 89g),several frag/grow out tanks, macroalgae refugia, cryptic zones. 40+ fish, seahorses, sps,lps,leathers, zoanthidae and non photosynthetic corals.